One of the most devastating pandemics in history, resulting in the deaths of an estimated 75 to 200 million people in Eurasia, or around one-third of the world population. Believed to have been brought from Asia through the Mongol conquests, it entered Europe through Sicily in 1347  AD and spread rapidly from there.

Because no explanation could be found, it was believed to be a divine punishment once again. Jewish communities suffered many attacks like the Strasbourg massacre of February 1349, where around 2000 Jews were murdered.